|
Disorder of tendon
|
0.010 |
Biomarker
|
group |
BEFREE |
Twenty patients with a diagnosis of patellar tendinopathy with imaging changes (tendon thickening and disruption of the intratendinous substance at the proximal portion of the patellar tendon) will be randomised in a 1:1 ratio to receive a local injection of either bone-marrow autologous mesenchymal stem cells (MSC), isolated and cultured under GMP at The Institute of Biology and Molecular Genetics (IBGM) (Spain) or P-PRP.
|
31842921 |
2019 |
|
Tendinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Twenty patients with a diagnosis of patellar tendinopathy with imaging changes (tendon thickening and disruption of the intratendinous substance at the proximal portion of the patellar tendon) will be randomised in a 1:1 ratio to receive a local injection of either bone-marrow autologous mesenchymal stem cells (MSC), isolated and cultured under GMP at The Institute of Biology and Molecular Genetics (IBGM) (Spain) or P-PRP.
|
31842921 |
2019 |
|
Tendon thickening
|
0.010 |
Biomarker
|
disease |
BEFREE |
Twenty patients with a diagnosis of patellar tendinopathy with imaging changes (tendon thickening and disruption of the intratendinous substance at the proximal portion of the patellar tendon) will be randomised in a 1:1 ratio to receive a local injection of either bone-marrow autologous mesenchymal stem cells (MSC), isolated and cultured under GMP at The Institute of Biology and Molecular Genetics (IBGM) (Spain) or P-PRP.
|
31842921 |
2019 |
|
Hypertensive disease
|
0.130 |
Biomarker
|
group |
BEFREE |
Of critical importance are vascular nitric oxide; nutrition; exercise; weight control and maintaining insulin sensitivity; early treatment of hypertension with attention to effects on erectile function; avoiding sources of oxidative stress such as obesity and smoking; reducing inflammation (e.g. from gingivitis); improving pelvic floor muscle strength; and inhibiting cyclic GMP break-down.
|
31724458 |
2019 |
|
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
Of critical importance are vascular nitric oxide; nutrition; exercise; weight control and maintaining insulin sensitivity; early treatment of hypertension with attention to effects on erectile function; avoiding sources of oxidative stress such as obesity and smoking; reducing inflammation (e.g. from gingivitis); improving pelvic floor muscle strength; and inhibiting cyclic GMP break-down.
|
31724458 |
2019 |
|
Gingivitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of critical importance are vascular nitric oxide; nutrition; exercise; weight control and maintaining insulin sensitivity; early treatment of hypertension with attention to effects on erectile function; avoiding sources of oxidative stress such as obesity and smoking; reducing inflammation (e.g. from gingivitis); improving pelvic floor muscle strength; and inhibiting cyclic GMP break-down.
|
31724458 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
The novel signatures were detected in 27% of relapsed ALLs and were responsible for 46% of acquired resistance mutations in NT5C2, PRPS1, NR3C1, and TP53.
|
31697823 |
2020 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The novel signatures were detected in 27% of relapsed ALLs and were responsible for 46% of acquired resistance mutations in NT5C2, PRPS1, NR3C1, and TP53.
|
31697823 |
2020 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The novel signatures were detected in 27% of relapsed ALLs and were responsible for 46% of acquired resistance mutations in NT5C2, PRPS1, NR3C1, and TP53.
|
31697823 |
2020 |
|
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that human MSCs generated according to apceth's GMP process from healthy donors are able to target and provide a significant growth inhibition in a glioblastoma model supporting a potential clinical translation.
|
31692882 |
2019 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that human MSCs generated according to apceth's GMP process from healthy donors are able to target and provide a significant growth inhibition in a glioblastoma model supporting a potential clinical translation.
|
31692882 |
2019 |
|
Childhood Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that human MSCs generated according to apceth's GMP process from healthy donors are able to target and provide a significant growth inhibition in a glioblastoma model supporting a potential clinical translation.
|
31692882 |
2019 |
|
Glioblastoma Multiforme
|
0.040 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that human MSCs generated according to apceth's GMP process from healthy donors are able to target and provide a significant growth inhibition in a glioblastoma model supporting a potential clinical translation.
|
31692882 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Cyclic GMP-AMP signalling protects bacteria against viral infection.
|
31533127 |
2019 |
|
Leishmaniasis, Cutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, leishmanization using Leishmania major produced under GMP guideline is a valuable tool to protect against CL, there are limitations which need further study.
|
31525323 |
2019 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here we present the clinical-scale production of CAR-T cells for the treatment of melanoma under full GMP compliance.
|
31426437 |
2019 |
|
Venous Thromboembolism
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The GMP-VTE project is a prospective, multi-center cohort study on individuals with objectively confirmed VTE.
|
31374513 |
2019 |
|
Influenza
|
0.020 |
Biomarker
|
disease |
BEFREE |
Nasal wash samples from 15 human volunteers challenged with GMP manufactured influenza A/California/04/2009(H1N1) and from 5 naturally infected influenza patients of the 2009 pandemic were deep sequenced using viral targeted hybridization enrichment.
|
31226666 |
2019 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nasal wash samples from 15 human volunteers challenged with GMP manufactured influenza A/California/04/2009(H1N1) and from 5 naturally infected influenza patients of the 2009 pandemic were deep sequenced using viral targeted hybridization enrichment.
|
31226666 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.350 |
Biomarker
|
disease |
BEFREE |
Direct targeting of NT5C2 or inhibition of compensatory pathways active in <i>NT5C2</i> mutant cells may antagonize the emergence of <i>NT5C2</i> mutant clones driving resistance and relapse in ALL.
|
30910786 |
2019 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Direct targeting of NT5C2 or inhibition of compensatory pathways active in <i>NT5C2</i> mutant cells may antagonize the emergence of <i>NT5C2</i> mutant clones driving resistance and relapse in ALL.
|
30910786 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Direct targeting of NT5C2 or inhibition of compensatory pathways active in <i>NT5C2</i> mutant cells may antagonize the emergence of <i>NT5C2</i> mutant clones driving resistance and relapse in ALL.
|
30910786 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found some of overexpressed genes of CC participated in GMP biosynthetic process.
|
30841438 |
2019 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found some of overexpressed genes of CC participated in GMP biosynthetic process.
|
30841438 |
2019 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found some of overexpressed genes of CC participated in GMP biosynthetic process.
|
30841438 |
2019 |